If you gonna separate then as Low-but-long-duration and High-but-low-duration nanos:
- Low ones: -1.5k DD -0 init debuff; 30~60s duration; no cooldown and impossibility to cast it if the nano is already running (hell I liked this system).
- High ones: -2.5~3k DD -500~600 init debuff; 10s duration; no cooldown; 10~15s immunity and impossibiliy to cast if the nano is already running.
Ofc, both shares the same line and both blocks eachother. ^^ Its the best I can think wih DR idea and that I find OK and not so freaking OP.