Speaking from MP point of view:
Unnerfing NR checks for support profs means that pretty much I can go and perk more folks with Starfall or the like now, so a nanoskill setup actually has a point. I like.
I'm meh about the change to Channel Rage's duration (2hrs) since I'd rather have beefier pets if you're going this route, but I'll take what I can get.
Changing the Soothing Spirits perk timers from 40s to 20 is nice, as is the Ancient Knowledge perk action...scaling too, so it's got potential. I think some MP will figure out how to hit 3k BM to unlock 3k heal/nanoheal at some point, I wasn't too far off from it on my creation setup.
Adding some nanoskills and NR to the AI perkline means it's actually useful, but I don't think having the one damage action check Evade Close and Dodge-Rng will do any good, if anything it should check NR and have TS/MC for attack skills as opposed to AR (MPs don't get good AR, unless it's a creation weapon)
I've browsed some of the other changes and I like what I'm seeing, however I'm curious to see what else is on the works for general/group perklines. I also note a lack of new perklines for MP, and I'm curious to see if there's any other planned changes to the perks.
All in all, I'll say it's a good start for the MP. Not great, but a good start, and if the rest of of the changes look like this it'll be interesting to see where MPs stand.