Okay,
I understand not being able to target characters in the surrounding rooms if the door is shut (I always thought it was some great futuristic targeting device I had, but what the hey).
However, because of the "hall of mirrors" problems with mission doors/rooms you cannot target NPCs in adjoining rooms even with open doors whilst it is going on. This can be pretty lethal on higher danger missions when trying to pull a single NPC from a room with multiple baddies as you have to physically enter the room to get the action going...
Cheers,
Hoss.
