"which wine" returns a link to a wrapper script which hasn't changed for some time. In theory you are right, but macports has some strange techniques to install packages to the system (not to speak of the inability to re-use precompiled object files - everytime i change the patch, the source is re-fetched, extracted, configured, patched and then built and installed)
Anyone knows if i have to recreate the WINEPREFIX each time i rebuild the code?