The professions I play:
Engineer - High nanoskill reqs, ip schism, easily kiteable pets, easily debuffable pets, easily killable pets, how long it takes to cast and buff pets
Bureaucrat - High flat immunities to CC, enforcer rage, ranged advs, easily debuffable pets, easily killable pets
Nano-Technician - NBG nanopool drain, blind immunity huds, dropping like a rock against anyone can perk 3k defs after shield ends, terrible heal delta, giant nanopool that takes forever to fill
Shade - Gotta be trox or expect to lose against evade profs by default, being unable to sneak around advs or those that get the adv buff and have maxed perception, slow sneak speed, drain perk line checks 100%, Totemic Rites healing depends on damage done (AMS...)
Meta-Physicist - Brings practically nothing of significant value to pvm teams, weak defense using bow, weak offense using Zset, easily kiteable pets, easily debuffable pets, easily killable pets, how long it takes to get pets ready, debuff toolset only partially updated, Sacrificial Shielding locks out casting