Seriously, what we need is mind bending addictive drugs that enhance our characters while hurting them in other ways.
Something like a roid drug for them enf's to get str/sta up and yet takes away some HP or something significant like that. And after being addicted, if you don't feed your need, you'd get negative effects for a withdrawel period of like 2 weeks (RL).
Maybe some other groovy stuff that would give you visuals and make you completely inept to fighting, but would make going to baboons quite interesting.
And what about the alchohol already in the game? How about control effects...your keyboard gets lag to what you are trying to do and the buttons switch around a tad bit to mess you up just enough.
I was disappointed to see I couldn't get my character drunk.